Brief Report LYMPHOID NEOPLASIA Multiparameter flow cytometry for staging of solitary bone plasmacytoma: new criteria for risk of progression to myeloma
نویسندگان
چکیده
Centro de Investigación Medica Aplicada, Clinica Universidad de Navarra, Pamplona, Spain; Hospital Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca, Instituto Mixto Consejo Superior de Investigaciones Cientı́ficas–Universidad de Salamanca Instituto de Biologı́a Molecular y Celular del Cáncer (IBMCC), Salamanca, Spain; Hospital Universitario Central de Asturias, Oviedo, Spain; Hospital Universitario Virgen del Rocio/Consejo Superior de Investigaciones Cientı́ficas/Universidad de Sevilla, Instituto de Biomedicina de Sevilla, Sevilla, Spain; Complejo Hospitalario de Leon, Leon, Spain; Hospital Clinico Universitario de Valladolid, Valladolid, Spain; and Hospital Virgen de la Concha, Zamora, Spain
منابع مشابه
Brief Report LYMPHOID NEOPLASIA Outcome prediction in plasmacytoma of bone: a risk model utilizing bone marrow flow cytometry and light-chain analysis
Solitary plasmacytoma of bone (SPB) is characterized by localized areas of bone destruction by monoclonal plasma cells in the absence of clinical, laboratory, and radiologic features of multiple myeloma (MM). Local irradiation remains the treatment of choice. United Kingdom national guidelines recommend doses of 40 to 50 Gy depending on tumor size, with a 2-cm margin, because this provides exce...
متن کاملMultiparameter flow cytometry for staging of solitary bone plasmacytoma: new criteria for risk of progression to myeloma.
Solitary plasmacytoma represents a heterogeneous group of patients; approximately half develop multiple myeloma (MM) in 2 or 3 years, whereas others remain disease-free at 10 years. By definition, these patients do not have morphologic bone marrow (BM) plasma cell (PC) infiltration. Here, we investigated whether sensitive BM evaluation of patients with solitary bone plasmacytoma (SBP; n = 35) a...
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In this issue of Blood, 2 studies, one by Paiva et al (for the Spanish Myeloma Study group) and one by Hill et al (for the Leeds group [UK]), showed independently that flow cytometry of the bone marrow could identify patients with solitary plasmacytomas (SPs) at high risk for progression to active multiple myeloma (MM). In the first study, 71% of patients with solitary bone plasmacytoma (SBP) w...
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Solitary plasmacytoma of bone is a rare malignant tumor mostly involving the axial skeleton. The tumor occurs in middle- aged or elderly people (mean age: 55 years) and has a high risk of progression to multiple myeloma. Radiotherapy is the preferred treatment for this disease. We report a case of recurrent solitary plasmacytoma of the fourth lumbar vertebra in a 35-year-old male. The patient s...
متن کاملOutcome prediction in plasmacytoma of bone: a risk model utilizing bone marrow flow cytometry and light-chain analysis.
The purpose of this study was to use multiparameter flow cytometry to detect occult marrow disease (OMD) in patients with solitary plasmacytoma of bone and assess its value in predicting outcome. Aberrant phenotype plasma cells were demonstrable in 34 of 50 (68%) patients and comprised a median of 0.52% of bone marrow leukocytes. With a median follow-up of 3.7 years, 28 of 50 patients have prog...
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